OcrV1, Main, Exploration, bibRecord, 000309

Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial

Identifieur interne : 000309 ( Main/Exploration ); précédent : 000308; suivant : 000310

Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial

Auteurs : Philip F. Bagshaw [Nouvelle-Zélande] ; Randall A. Allardyce [Nouvelle-Zélande] ; Christopher M. Frampton [Nouvelle-Zélande] ; Francis A. Frizelle [Nouvelle-Zélande] ; Peter J. Hewett [Australie] ; Paul J. Mcmurrick [Australie] ; Nicholas A. Rieger [Australie] ; J. Shona Smith [Nouvelle-Zélande] ; Michael J. Solomon [Australie] ; Andrew Rl. Stevenson [Australie]

Source :

Annals of surgery [ 0003-4932 ] ; 2012.

RBID : Pascal:13-0048936

Descripteurs français

Pascal (Inist)
- Chirurgie, Long terme, Evolution, Cancer du côlon, Pronostic, Essai clinique, Australasie, Etude comparative, Laparoscopie, Traitement, Médecine.
Wicri :
- topic : Chirurgie, Médecine.

English descriptors

KwdEn :
- Australasia, Clinical trial, Colon cancer, Comparative study, Evolution, Laparoscopy, Long term, Medicine, Prognosis, Surgery, Treatment.

Abstract

Objective: We report a multicentered randomized controlled trial across Australia and New Zealand comparing laparoscopic-assisted colon resection (LCR) with open colon resection (OCR) for colon cancer. Background: Colon cancer is a significant worldwide health issue. This trial investigated whether the short-term benefits associated with LCR for colon cancer could be achieved safely, without survival disadvantages, in our region. Methods: A total of 601 patients with potentially curable colon cancer were randomized to receive LCR or OCR. Primary endpoints were 5-year overall survival, recurrence-free survival, and freedom from recurrence rates, compared using an intention-to-treat analysis. Results: On April 5, 2010, 587 eligible patients were followed for a median of 5.2 years (range, 1 week-11.4 years) with 5-year confirmed follow-up data for survival and recurrence on 567 (96.6%). Significant differences between the 2 trial groups were as follows: LCR patients were older at randomization, and their pathology specimens showed smaller distal resection margins; OCR patients had some worse pathology parameters, but there were no differences in disease stages. There were no significant differences between the LCR and OCR groups in 5-year follow-up of overall survival (77.7% vs 76.0%, P = 0.64), recurrence-free survival (72.7% vs 71.2%, P = 0.70), or freedom from recurrence (86.2% vs 85.6%, P = 0.85). Conclusions: In spite of some differences in short-term surrogate oncological markers, LCR was not inferior to OCR in direct measures of survival and disease recurrence. These findings emphasize the importance of long-term data in formulating evidence-based practice guidelines.

Affiliations:

Australie, Nouvelle-Zélande

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Le document en format XML

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<author><name sortKey="Solomon, Michael J" sort="Solomon, Michael J" uniqKey="Solomon M" first="Michael J." last="Solomon">Michael J. Solomon</name>
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<s3>AUS</s3>
<sZ>9 aut.</sZ>
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</author>
<author><name sortKey="Stevenson, Andrew Rl" sort="Stevenson, Andrew Rl" uniqKey="Stevenson A" first="Andrew Rl." last="Stevenson">Andrew Rl. Stevenson</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Colon and Rectal Surgery, Royal Brisbane & Women's Hospital</s1>
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<series><title level="j" type="main">Annals of surgery</title>
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<term>Clinical trial</term>
<term>Colon cancer</term>
<term>Comparative study</term>
<term>Evolution</term>
<term>Laparoscopy</term>
<term>Long term</term>
<term>Medicine</term>
<term>Prognosis</term>
<term>Surgery</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Chirurgie</term>
<term>Long terme</term>
<term>Evolution</term>
<term>Cancer du côlon</term>
<term>Pronostic</term>
<term>Essai clinique</term>
<term>Australasie</term>
<term>Etude comparative</term>
<term>Laparoscopie</term>
<term>Traitement</term>
<term>Médecine</term>
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<front><div type="abstract" xml:lang="en">Objective: We report a multicentered randomized controlled trial across Australia and New Zealand comparing laparoscopic-assisted colon resection (LCR) with open colon resection (OCR) for colon cancer. Background: Colon cancer is a significant worldwide health issue. This trial investigated whether the short-term benefits associated with LCR for colon cancer could be achieved safely, without survival disadvantages, in our region. Methods: A total of 601 patients with potentially curable colon cancer were randomized to receive LCR or OCR. Primary endpoints were 5-year overall survival, recurrence-free survival, and freedom from recurrence rates, compared using an intention-to-treat analysis. Results: On April 5, 2010, 587 eligible patients were followed for a median of 5.2 years (range, 1 week-11.4 years) with 5-year confirmed follow-up data for survival and recurrence on 567 (96.6%). Significant differences between the 2 trial groups were as follows: LCR patients were older at randomization, and their pathology specimens showed smaller distal resection margins; OCR patients had some worse pathology parameters, but there were no differences in disease stages. There were no significant differences between the LCR and OCR groups in 5-year follow-up of overall survival (77.7% vs 76.0%, P = 0.64), recurrence-free survival (72.7% vs 71.2%, P = 0.70), or freedom from recurrence (86.2% vs 85.6%, P = 0.85). Conclusions: In spite of some differences in short-term surrogate oncological markers, LCR was not inferior to OCR in direct measures of survival and disease recurrence. These findings emphasize the importance of long-term data in formulating evidence-based practice guidelines.</div>
</front>
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<affiliations><list><country><li>Australie</li>
<li>Nouvelle-Zélande</li>
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<name sortKey="Allardyce, Randall A" sort="Allardyce, Randall A" uniqKey="Allardyce R" first="Randall A." last="Allardyce">Randall A. Allardyce</name>
<name sortKey="Frampton, Christopher M" sort="Frampton, Christopher M" uniqKey="Frampton C" first="Christopher M." last="Frampton">Christopher M. Frampton</name>
<name sortKey="Frizelle, Francis A" sort="Frizelle, Francis A" uniqKey="Frizelle F" first="Francis A." last="Frizelle">Francis A. Frizelle</name>
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<country name="Australie"><noRegion><name sortKey="Hewett, Peter J" sort="Hewett, Peter J" uniqKey="Hewett P" first="Peter J." last="Hewett">Peter J. Hewett</name>
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<name sortKey="Mcmurrick, Paul J" sort="Mcmurrick, Paul J" uniqKey="Mcmurrick P" first="Paul J." last="Mcmurrick">Paul J. Mcmurrick</name>
<name sortKey="Rieger, Nicholas A" sort="Rieger, Nicholas A" uniqKey="Rieger N" first="Nicholas A." last="Rieger">Nicholas A. Rieger</name>
<name sortKey="Solomon, Michael J" sort="Solomon, Michael J" uniqKey="Solomon M" first="Michael J." last="Solomon">Michael J. Solomon</name>
<name sortKey="Stevenson, Andrew Rl" sort="Stevenson, Andrew Rl" uniqKey="Stevenson A" first="Andrew Rl." last="Stevenson">Andrew Rl. Stevenson</name>
</country>
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</affiliations>
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Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial

Long-Term Outcomes of the Australasian Randomized Clinical Trial Comparing Laparoscopic and Conventional Open Surgical Treatments for Colon Cancer: The Australasian Laparoscopic Colon Cancer Study Trial

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri